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Out and about: Puffing on a cigarette as they enjoyed a stroll together, Louis seemed in excellent spirits as he no doubt filled his sister in on all his latest exploits Low-key: Keeping things casual for the outing, Louis donned a baggy grey jumper that he teamed with black jogging bottoms and a baseball cap The pair met when he auditioned on the 2010 series of The X Factor, going on to join one of the show's most successful boybands One Direction

AUTHORS CONTRIBUTIONS MHRS, MM, HS and ASGF designed the study