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In support of this work, a randomised controlled trial (RCT) of low-dose (400 IU/day) vitamin D 3 supplementation (compared to placebo) in vitamin D-deficient (mean 25-hydroxy vitamin D [25(OH)D Footnote 1 ] blood concentration = 36.1 nmol L 1 ) but otherwise healthy participants in Aberdeen, Scotland, found seasonal variation in natural T-regulatory cell populations and functions that was independent of blood 25(OH)D concentration [24]

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