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E-cigarette users may habituate to the aversive pharmacological effects of nicotine and become sensitized to nicotines addictive effects (e.g., pleasure, anxiolysis) due to nicotine-induced neurobiological changes (Lydon et al., 2014), which would enhance the first few combustible tobacco cigarette smoking experiences

Rates also soared during the Great Plague of the 17th Century, when tobacco smoke was believed to afford protection

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