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Different views on the topic The authors characterization of cannabis use as an extreme addiction represents an anomalous experience rather than a typical user outcome [1] , suggesting that most people who have tried marijuana do not develop the level of dependence or life dysfunction the author experienced, and that personal anecdotal accounts may overstate the prevalence and severity of cannabis addiction in the general population.

EMT is characterized by downregulation of the intercellular tight junctions and acquire certain properties of mesenchymal cells