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I guess where we may differ is the balance we strike between the well proven harms of the most harmful consumer product known to man on one hand and the very uncertain harms of alternatives that may provide a way out

Its a vicious cycle that hurts both their mental and physical health

Participants younger than 60 years (n = 285,022), without ethnic background information (n = 1182) or not White British (n = 17,400), with missing APOE genotype information (n = 5324) or 1 allele (n = 25), with unmatched self-reported sex and genetic sex (n = 121) and excessive relatives (n = 88), and with dementia at baseline or prior to recruitment (n = 145) were excluded (Supplementary Fig