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However, even in 2021, the most recent year for which such data are available, an estimated 46 million US adults reported using any tobacco product (e.g., cigarettes, cigars, pipes) (49)

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Nitric acid solution (HNO 3 65%), Hydrochloric acid solution (35%) and ammonia solution (30%) were purchased from Carlo-Erba (Reactolab, Switzerland) and were analytical grade