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One limitation of our study is the extrapolation of data from mouse models to human COPD progression, as differences in respiratory systems and immune responses between species can affect the applicability of these findings to humans

Dimensions: 2731 x 4096 px | 23.1 x 34.7 cm | 9.1 x 13.7 inches | 300dpi Date taken: 1 June 1982 Photographer: Don Morley More information: This image could have imperfections as its either historical or reportage

Reduced chronic toxicity and carcinogenicity in A/J mice in response to life-time exposure to aerosol from a heated tobacco product compared with cigarette smoke

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Second, responses to questions were self-reported and were not validated by biochemical testing