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Significant effects from treatment with the IQOS heated tobacco product extracts were only observed at very high, non-physiologically relevant concentrations whilst extracts from the Marlboro conventional cigarette significantly reduced alkaline phosphatase activity and matrix mineralisation at low concentrations

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Given the complications of rigorously controlling the variables sex means different things to different people Grunberg added that it would be "difficult to do a true controlled experiment" investigating the question, but offered a tentative hypothesis

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For the record, Phoenix says, he does personally believe that Fleck is the actual Joker