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Type 3 DDIs: CYP2D6 or CYP3A4 inhibitors Co-treatment of clozapine with antidepressants metabolized by CYP2D6 including sertraline, paroxetine and fluoxetine, is reported to lead to increases of plasma clozapine by 2040% (reviewed in [60])

Incapsula incident ID: 535000740000707224-3710250483389074

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Similar prior studies included those by Jiang et al