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For some reason, every year when I work part-time at a convenience store, someone who just got out of the US comes looking for this on January 1st

This suggests an additional risk beyond total smoking dose as measured by pack-years, while acknowledging that initiation age and lifetime exposure remain closely related behaviors

Volatile chemicals like formaldehyde, acrolein, benzene and certain N-nitrosamines, can also be contained in the liquid-vapor of the smoke aerosol, which also consists of nicotine, phenol, polyaromatic hydrocarbons (PAHs) and certain tobacco-specific nitrosamines (TSNAs)

Work down the list until its gone

Nicotine causes narrowing of the blood vessels, which can lead to increased pressure on ones heart