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At 2 weeks early stage of the study, edematous changes, severe parenchymal erosion, cellular necrosis, vacuolations, hemorrhagic exudations and severe hemorrhage, distortions in parenchymal tissue architecture, inflammatory and necrotic cells with vacuolations and eosinophilic cells-indicative of cellular degeneration were observed in group B, C and D which shows hepatic alterations Fig