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16 Additionally, when intracellular cholesterol is excessive, sterol regulatory element-binding protein cleavage-activating protein (SCAP) undergoes conformational changes, preventing SREBP2 from being cleaved in the Golgi apparatus and entering the nucleus to activate target gene transcription

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When the US Food and Drug Administration (FDA) tried to force tobacco companies to print health warnings and pictures of negative health consequences on cigarette packages, tobacco firms successfully argued that it would unconstitutionally violate their rights to freedom of speech under the First Amendment

Symptoms include coughing, wheezing, shortness of breath, and chest pain