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Nicotine promotes angiogenesis, cell proliferation, epithelial-mesenchymal transition, vascular remodeling and dysfunction, inflammation, and oxidative stress in vascular smooth muscle cells causing atherosclerosis, dendritic cell morphology changes, and neuronal signaling, which may lead to mental disorders like depression, addiction, and attention deficit (4653)

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JAMA Internal Medicine Some health advocates say that even if the the company's health claims are true, they are concerned that the product will hook a new generation of Americans on nicotine, halting the reduction of smoking rates in America, now at an all-time low