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Conversely, Staudt et al., in a trial with healthy non-smoking subjects exposed to both nicotine-containing and nicotine-free e-cigarettes, noted genetic changes in small airway epithelial cells, alveolar macrophages, and lower airway mononuclear phagocytes after short exposure to EC aerosols

Beyond nicotine, the flavoring chemicals in e-liquids contribute significantly to aerosol composition and toxicity

Since everyone develops different habitual smoking patterns, considering different methods and maybe a trial and error approach may be beneficial