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The tobacco industry has been working for years to move their business from traditional cigarettes and cigars to e-cigarettes, vaping devices, and other Electronic Nicotine Delivery Systems (ENDS)

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All were odorless except one, he wrote, which smelled like green apples. Perfetti synthesized 30 different nicotine salt concoctions, then heated them like a smoker would in pursuit of the maximum release of nicotine. He also tested the salts ability to dissolve into a liquid a trait that would decades later become central to vaping products like Juul