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Repeated exposure to nicotine results in the development of tolerance, the condition in which higher doses of a drug are required to produce the same initial stimulation

For example, some e-cigarettes marketed as containing zero percent nicotine have been found to contain nicotine, and many contain nicotine salts

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Cotinine can be a marker to detect exposure to nicotine as it has high sensitivity and its half-life is longer than other nicotine metabolites

Use flowering tobacco in masses at the back of the annual or mixed border as a stunning backdrop for smaller plants, as a tall accent plant, or in a large mixed container