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Chelators non-selectively deplete systemic copper, harming healthy organs that require copper for normal function and leading to systemic deficiency [240]

Other peptide agents such as GHK-Cu are marketed for wound healing and connective tissue repair, while growth hormone secretagogues and IGF-1 analogs are increasingly used in performance settings and may plausibly influence recovery physiology through systemic endocrine pathways (Pickart and Margolina 2018)

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Although glucose is the major fuel whose oxidation leads to energy-coupled insulin secretion, a process referred to as glucose-stimulated insulin secretion (GSIS), there are other means for stimulated insulin secretion