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GLP-1 receptor agonists, including semaglutide, have been studied for their role in reducing inflammation

Indeed, filing in territories such as the US means that protection of, e.g., methods of treatment, can be obtained, which are excluded from patentability in territories including Europe and Japan

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Mele C, Caputo M, Bisceglia A, Sam MT, Zavattaro M, Aimaretti G et al (2020) Immunomodulatory Effects of Vitamin D in Thyroid Diseases

Moreover, our recent studies have reported that glutamatergic neurons in the medial septum (MS) of the basal forebrain encode negative-valence sensory events and drive avoidance behavior (Zhang et al., 2018a,2018b), while its GABAergic neurons, specifically those expressing somatostatin, encode positive-valence events and drive appetitive behavior (Shen et al., 2022)