When HbA 1c was measured in %, tirzepatide at doses of 15 mg, 10 mg and 5 mg demonstrated greater efficacy than semaglutide at doses of 2.0 mg (MD = 0.38% [95% CI 0.75% to 0.01%]), 1.0 mg (MD = 0.45% [95% CI 0.60% to 0.31%]) and 0.5 mg (MD = 0.51% [95% CI 0.68% to 0.33%]), respectively (ESM Table 7)
That's when liquid protein becomes essential , not just optional
The exact mechanism is unclear, GLP-1s interact with brain pathways involved in appetite and autonomic regulation, and might be changing how you perceive sensations like warmth and cold, potentially making you more sensitive than youd otherwise be
Some people experience semaglutide related fatigue or semaglutide fatigue, which is distinct from general tiredness
Why does the shedding coincide with the dose increase