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First, melatonin activates AMPK to regulate autophagy under different pathological conditions, such as myocardial ischemia-reperfusion injury (Zhang et al., 2019), doxorubicin-induced cardiotoxicity (Liu et al., 2018), PBDE-47 neurotoxicity (McCarty et al., 2022), and lipopolysaccharide-induced blood-brain barrier injury (Wang et al., 2017)

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Constipation can still occur after three months, and its timeline is not as clearly described as the pattern for nausea, vomiting, and diarrhea

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