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Retatrutide improved fasting lipid profiles including triglycerides, very low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol in clinical trials in people with T2D or obesity, while low-density lipoprotein cholesterol was reduced in people with obesity 12,13,28

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In November 2024, Phase II data for MariTide showed that the drug elicited up to 20% weight loss on average at 52 weeks in patients who were overweight or had obesity