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For BSO group, a week later, mice received intraperitoneal administration of 750 mg/kg of body weight BSO (B113387, Aladdin) in phosphate-buffered saline (pH 7.4) once a day for two weeks 25

Oliveira G, Diogo L, Oliveira CR, et al

In addition, ferroptosis inhibition prevented A pathology, decreased lipid peroxidation and restored iron storage in human AD iPSCs-derived brain cortical organoids at day 50 of differentiation

Covalent/irreversible inhibitors target the redox/catalytic apparatus of TGR with almost no recognition elements that give affinity and selectivity for TGR over off-targets and the cellular redox apparatus resulting in undesirable cross-reactions and low specificity in vivo 25

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