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By weeks 912 (typically at your second or third dose increase), many patients experience peak hunger suppression and enter consistent 23 pound weekly loss phases
10.1186/s12951-020-00703-5 31 YeZ.LiuR.WangH.ZuoA.JinC.WangN.et al (2025)
Evidence is growing that these are not rare side-effects
Night sweats are essentially hot flashes that happen during sleep, but they often feel more intense because the body is horizontal and covered by bedding
Initial concerns were raised after findings from the cardiovascular outcome trial (CVOT), Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes 6 (SUSTAIN 6), revealed a greater risk of DR-related complications, defined as the need for laser therapy, intravitreal injections, development of vitreous hemorrhage, and blindness, in semaglutide users compared to placebo (3.0% vs 1.8%, HR=1.76, P =.02)
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