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Key variants in GLP1R, GIPR, FTO, and MC4R genes can affect appetite signaling, energy metabolism, and gastrointestinal sensitivity, potentially shaping which GLP-1 formulation works best

Patients may be prescribed semaglutide if metformin therapy is not enough for diabetic control

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Covers: biochemistry of amylin, receptor biology (CTR + RAMP complex), physiological functions, clinical applications, the Pramlintide experience, perspectives for long-acting analogs