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Quick answer: In the Phase 2 clinical trial (Jastreboff et al., 2023, New England Journal of Medicine ), retatrutide was given by once-weekly subcutaneous injection across a 112mg range

Interestingly, men are twice as likely to develop PD as women, however women have a higher mortality rate from PD with a more rapid disease progression 46

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Metabolic Improvements Beyond the scale, people take this medication for the secondary health benefits

In research, it is studied mainly for tissue repair, and it is known for acting locally at the site of injury rather than systemically