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Another breakthrough in obesity medication acceptance was the SELECT trial [7], the first cardiovascular outcome trial in persons with overweight and obesity with established cardiovascular disease (prior myocardial infarction, stroke or symptomatic peripheral artery disease) to show reduction in major adverse cardiovascular events (MACE) [7]

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[79], which compared metformin, clomifene citrate, and pioglitazone, but did not include emerging drug therapies such as GLP-1 RAs and SGLT2is