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Patients reported to the laboratory before the operation and 68 months after the operation to receive in random order, on separate days, after fasting overnight for at least 10 h, 300 ml of orange juice (containing 27 g of carbohydrate sugar) supplemented with either 25 g oligofructose-enriched inulin (inulin, OraftiSynergy1, ~92% inulin content, BENEO GmbH, Mannheim, Germany), or an equicaloric load of 15.5 g maltodextrin (MDX, Nutricia GmbH, Erlangen, Germany, see Supplemental Table 1)

Levothyroxine therapy may be given with the hope of suppressing benign nodule growth, though its use is still controversial (Tanase et al

HGPRT catalyzes the following two interconversions: hypoxanthine + PRPP IMP + PP i guanine + PRPP GMP + PP i A complete or virtually complete loss of HGPRT activity results in the severe disorder, Lesch-Nyhan syndrome

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GLP-1 receptor agonists are generally safe for patients with hypertension, but blood pressure should be monitored regularly as part of routine care