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This increases histamine levels in different tissues, such as in the skin, causing itching and hives.[ref] Metabolism of alcohol: creating acetaldehyde Ive mentioned acetaldehyde a couple of times without really explaining it Alcohol goes through a multistep process to be broken down and eliminated by the body.[ref] Alcohol is first metabolized by alcohol dehydrogenase (ADH genes) into acetaldehyde, which is toxic