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The STEP trials showed that symptoms were most pronounced during the 16-week titration period and diminished significantly once participants reached their maintenance dose (Wilding et al., 2021)
It explains concepts like peak concentration, trough levels, and accumulation in plain language with visual examples
GLP-1s are following the same arc: transformative but incomplete on their own
Compared with placebo or other interventions, GLP-1 receptor agonists use showed an association with an increased risk of overall thyroid disorders (RR 1.28, 95% CI 1.03-1.60)
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