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Placebo-adjusted changes in time in range, weight and HbA1c were 6.2 (9.7) percentage points, 6.3 (5.7) kg and 0.7% (0.3) in those with detectable C-peptide levels compared to 4.4 (7.1) percentage points, 6.4 (3.4) kg and 0.4% (0.3) in those with undetectable levels (Supplementary Table 11)

If you began b12 due to pre-existing deficiency, dietary restrictions, or other risk factors independent of semaglutide, continue supplementation after stopping the medication

Tirzepatide's dual-pathway action produces faster weight loss in clinical trials, but semaglutide causes fewer GI side effects in some patients

Never freeze Ozempic or expose it to excessive heat

Was associated with a lower risk of cognitive problems and nicotine dependence Our results suggest that semaglutide use could extend beyond managing diabetes, potentially offering unexpected benefits in the treatment and prevention of cognitive decline and substance misuse, said Dr Riccardo De Giorgi, Clinical Lecturer at the University of Oxfords Department of Psychiatry and lead author of the study