Indeed, a phase 2 mechanistic trial (NCT05936151) investigating change in eGFR from baseline to week 24 with multiple doses of retatrutide vs
doi: 10.1369/jhc.2008.951319, 148 TreesukosolY.MoranT
A study in female patients with obesity who were prescribed a 925 kcal diet for 16 weeks followed by a 12001500 kcal diet for 32 weeks showed 11% weight loss in the first 2 months with reductions in triglycerides and total cholesterol by 22.7% and 15.7% respectively [29]

Although low frequency of cardiovascular complications have been reported,9,1417 two recent publications found that patients with chronic hepatitis C showed an increase of carotid intimal layer thickness, the number of carotid plaques and the extent of atherosclerosis compared with control subjects.2427 In another study, the prevalence of non-obstructive coronary artery disease was similar in cirrhotic and non-cirrhotic individuals and it was associated with traditional risk factors, particularly DM.28 The impact of DM also extends to immunocompetence, and can increase the risk of severe infection, such as spontaneous bacterial peritonitis.29 Cirrhotic patients with such infections exhibit liver failure and hepatorenal syndrome, and have a high hospital mortality.30 Treatment of DM in Patients with Chronic Liver Disease The effective control of hyperglycemia may reduce complications and mortality rate in patients with DM and chronic liver disease
Using this new technology, Habener et al