Rybelsus (oral semaglutide): FDA-approved for type 2 diabetes, taken once daily on an empty stomach
In addition, when used with cisplatin, EGCG enhanced cytotoxicity and reduced kidney toxicity (El-Mowafy 2010)
Specifically, genes associated with synaptogenesis, calcium signaling, long-term potentiation, and dopamine signaling were suppressed in cortical neurons
More recently, it has been demonstrated that NSC-34 cells expressing TDP-43 mutants also exhibit shortened neurites, increased OS, and decreased HO1 level, and these effects can be reversed by the UPS inhibitor MG132, but not by the Nrf2 activator sulforaphane [255, 256], probably because MG132 induction of HO1 is Nrf2 independent
NQO1, NAD(P)H Oxidoreductase 1