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In the CNS, zinc released from nerve endings activates the MAPK pathway, inducing neuronal apoptosis, MMP-9-dependent BBB disruption, and microglial activation, which in turn releases proinflammatory cytokines, ultimately damaging the myelin sheath [284]

Animal models, for example, have shown better results when researchers administer oral peptides like GHK-Cu capsules rather than injections, as it reduces stress and the need for repetitive handling

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