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These medicines work by harnessing gut-brain hormonal pathways to reduce appetite and change food intake behaviour, a far more targeted approach than telling patients only to eat less and move more

Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns

1,336,337 Doa10, an ortholog of MARCHF6, is a large transmembrane protein with multiple membrane-spanning domains and is localized at the ER and inner nuclear membrane in yeast

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In the endoplasmic reticulum, it also acts like a built-in quality-control partner, supporting proper protein folding and helping prevent misfolded proteins from accumulating