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In the UK, medications like semaglutide (Wegovy) and tirzepatide (Mounjaro) are now being prescribed for weight management alongside diet and exercise

Although these trials primarily enrolled individuals with relatively low DKD risk and were not designed to evaluate kidney outcomes specifically, exploratory analyses consistently indicated slower kidney disease progression across diverse eGFR and albuminuria levels [39-44]

GLP-1R neurons in the DMH and other hypothalamic nuclei regulate multiple aspects of eating behavior, presenting potential therapeutic targets for GLP-1R-based therapies and other drug candidates

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Sensitivity analyses using MR-Egger, weighted median, weighted mode, simple mode, maximum likelihood, and RAPS (Supplementary Table S4) showed consistent directionality of effects for schizophrenia, anxiety disorders, and autism