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In DIO mice, a single injection of GLP-1 or MK-801-GLP-1 lowered blood glucose levels, but equimolar MK-801 therapy had no meaningful effect on glycemia

doi: 10.1016/j.steroids.2014.04.005

Both are still on the market, but new prescriptions are increasingly going to semaglutide- or tirzepatide-based options because of greater effectiveness on blood sugar and weight

Even if you use TomorrowsRx, your primary care provider should be aware of any prescription medications you're taking, including weight loss medications, so they can coordinate your overall care effectively

Once-Monthly Obesity Medication Shows Promise for Those With and Without Type 2 Diabetes. July 17, 2025