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The FDA requires stopping these medications at least two months before attempting conception, based on animal reproduction studies showing possible developmental risks

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The primary endpoint was to determine whether orforglipron could achieve statistically significant efficacy results in improving glycemic control compared to placebo, as measured by reductions in HbA1c levels

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Practical Scripts: What to Tell Your Doctor at the Next Visit Use precise language: say when the mood changes started, describe frequency and severity, and mention any suicidal thoughts or sleep changes