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indicates that an imbalance in the gut microbiota (lower abundance of several Clostridium species) and a reduction in SCFAs are associated with the onset of obesity ( SCFAs are important metabolites produced by the gut microbiota that affect glucose and lipid metabolism

Prioritizing protein, healthy fats, and fiber while reducing highly processed foods can support metabolism, muscle retention, and sustained weight loss

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Consequently, contemporary guidance has shifted toward individualized risk assessment rather than universal medication withholding