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A comprehensive multivitamin, vitamin B12, vitamin D, and adequate protein supplementation are recommended with both medications

Besides, it has been established that PFKFE3 delays the development of OA by regulating the PI3K/Akt/C/EBP homologous protein (CHOP) signaling pathway

Usually, its 100 mg thiamine and 1,000 mcg B12

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Alterations in the essential energy substrates, such as glucose and lipids, may enhance the accumulation of ROS and initiate the peroxidation of PUFAs, thereby increasing the susceptibility to ferroptosis [79]