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Chronic hyperglycemia further exacerbates hepatocellular injury through multiple mechanisms: excessive glucose activates the polyol pathway, depleting NADPH and inducing oxidative stress, while advanced glycation end-products (AGEs) trigger inflammatory cascades via the RAGE/NF-B axis, thereby accelerating hepatic fibrogenesis (4648)
T2DM was diagnosed according to the diagnostic criteria in the Chinese Guidelines for the Prevention and Control of Type 2 Diabetes Mellitus (2020), as shown in Supplementary Table S1
Comparison of the efficacy of MOE and PMO modifications of systemic antisense oligonucleotides in a severe SMA mouse model
When injected near an injury site, this peptide has been shown to significantly enhance recovery and reduce inflammation
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