The compound interacts with nitric oxide pathways, which regulate blood flow and tissue oxygenation in the gut lining
Some have called for the FDA to reconsider its recommendations, but no changes made to date
Study Design Type: Phase 2, double-blind, randomized, placebo-controlled study Participants: 338 adults (BMI 30 or BMI 27 with a coexisting condition) Groups: Retatrutide 1 mg, 4 mg, 8 mg, 12 mg (different initial doses 2 or 4 mg) and placebo Duration: 48 weeks (plus 4 weeks follow-up) Administration: subcutaneous, 1x weekly Primary endpoint: percentage change in body weight at week 24 Secondary endpoints: change in weight at week 48, 5%, 10%, 15% weight reduction
In fact, the liver stores so much B12 that it can take years for a deficiency to develop (EFSA, 2015
It works by blocking the NNMT enzyme in fat cells and other tissues, which prevents the conversion of nicotinamide to 1-methylnicotinamide