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Deficient ARSA activity leads to the accumulation of sulfatide glycolipids, which leads to demyelination of central and peripheral nervous systems, and thus causes severe neurological dysfunctions including motor dysfunction, developmental delay, hyperactivity, lack of communication, coordination, speech problems, behavioral disturbance, and in worst-case scenario it may lead to death [6,7,8,9]

10.1016/j.nbd.2009.07.008 56 KimJ.-H.NaH.-J.KimC.-K.KimJ.-Y.HaK.-S.LeeH.et al (2008)

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