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334 Beyond degradation failure, autophagy-lysosomal dysfunction contributes to the pathological propagation of aggregation-prone proteins

Peters longevity-focused nutrition principles [52:15]

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Bacteriostatic water's 0.9% benzyl alcohol preservative prevents bacterial growth in reconstituted solutions, extending stable storage from 72 hours to 28-30 days when refrigerated

These results are not unprecedentedour lab has shown that some RNA viruses target host mRNAs encoding isoforms of thioredoxin reductase via RNA:RNA antisense interactions, which, like proteolysis, would likely also result in host selenoprotein knockdown, but by a different mechanism ( Understanding why RNA viruses may have developed such strategies presents an interesting challenge for future research