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The FDA has determined that NAC is excluded from the statutory definition of a dietary supplement under the Federal Food, Drug, and Cosmetic Act, because NAC was authorized as an active pharmaceutical ingredient (for acetaminophen overdose) before it was widely marketed as a supplement

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Retrieved September 23, 2021, from Ishaque, S., Shamseer, L., Bukutu, C., & Vohra, S

It was not until the development of an in-vitro carnitine uptake assay on cultured fibroblast, a clear-cut definitive diagnosis of CUD could be made.2 However, in-vitro functional assay has many limitations and the most obvious one is the unavailability of living fibroblast as fibroblast culture from skin biopsy is not a routine investigation that is readily available

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