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If vitamin B12 deficiency due to recreational use of nitrous oxide is suspected, homocysteine or methylmalonic acid should be the initial test as nitrous oxide inactivates the vitamin B12 molecule, which can result in normal total and active B12 concentrations despite tissue deficiency

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Inflammatory bowel disease represents the most advanced clinical target, with at least one Phase II trial having examined a BPC-157-derivative compound (PL 14736) for ulcerative colitis, showing preliminary evidence of mucosal healing in human patients

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