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The development of transporter-utilizing (pro)drugs and nanocarriers for improved brain delivery begins from the understanding whether the poor efficacy of the drug is caused by low extent of the brain permeation and inadequate concentrations of the drug at target site or due to other reasons

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The compound's therapeutic potential stems from its ability to modulate multiple cellular pathways, including extracellular matrix synthesis, metalloproteinase regulation, and inflammatory mediator control

These results established tirzepatide as one of the most effective peptides for weight loss studied to date

injectable route