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It provides an exclusivity floor for all biologics regardless of patent strength, ensuring that early biosimilar entry cannot occur even for biologics with weak or nonexistent patent protection

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However, the scale and consistency of patient-reported experiences have suggested that these signals merit further investigation

HIF-1 downregulation increases ACSL4 to promote ferroptosis, and Nrf2 mediates HIF-1 activation to alleviate ischemic AKI (102)

CVD is a well-known comorbidity of diabetes, and the MetS is by definition also associated with a higher risk of CVD