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Drug metabolising enzymes carry out the metabolism of endogenous as well as exogenous substances

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They take it at night because it's convenient, or with breakfast because they forget to dose earlier, and when results are inconsistent they assume the peptide doesn't work or their batch is underdosed

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However, if you think you know which proteins might be interacting with your protein of interest, perhaps based on their size and biological context, then you could do a Western blot using antibodies against the proteins you think they are