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If OK, push plunger slowly over 510 seconds to ease discomfort

These trials prioritize patient-centric endpoints (e.g., DAS28 scores and quality-of-life metrics) but face recruitment challenges due to RA heterogeneity and stringent inclusion criteria (54)

Thiol redox status regulate MPT and enhanced ROS generation can target critical cysteine residues in cyclophilin D, implying that mGSH depletion would favor MPT via redox pathways targeting MPT components

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