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Canis M, Donnez JG, Guzick DS, Halme JK, Rock JA, Schenken RS, et al

Copper is a required cofactor for lysyl oxidase (connective-tissue crosslinking), for superoxide dismutase (antioxidant defense), and for enzymes that support angiogenesis, so a molecule that delivers copper in a controlled, cell-usable form has a coherent reason to influence tissue remodeling and vascular biology

[DOI] [PubMed] [Google Scholar] 62.Rogliani P., Calzetta L., Cavalli F., Matera M.G., Cazzola M

Pickart compares this resetting effect to how a piano must be periodically fine-tuned to maintain melodic balance